Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.
نویسندگان
چکیده
Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 microg/mL.
منابع مشابه
Xanthone derivatives from Cratoxylum cochinchinense roots.
Two xanthones and two caged-prenylated xanthones, named cochinchinones A-D, respectively, and a synthetically known caged-prenylated xanthone, together with seven known compounds were isolated from the roots of Cratoxylum cochinchinense (Lour.) Blume. Their structures were assigned on the basis of analyses of spectroscopic data. Some of the compounds exhibited effective antioxidative properties.
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عنوان ژورنال:
- Molecules
دوره 14 4 شماره
صفحات -
تاریخ انتشار 2009